Tg(Myh6-Gsk3b*)19Jusa
Transgene Detail

Summary

• Symbol: Tg(Myh6-Gsk3b*)19Jusa
• Name: transgene insertion 19, Junichi Sadoshima
• MGI ID: MGI:5471797
• Synonyms: DnGSK-3beta, Tg-GSK-3beta-KI
• Transgene: Tg(Myh6-Gsk3b*)19Jusa Location: unknown
• Alliance: Tg(Myh6-Gsk3b*)19Jusa page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The promoter drives cardiac-specific expression of a modified cDNA in which nucleotide susbtitutions result in the amino acid substitution of methionine for lysine at position 85 (K85M) and isoleucine for lysine at position 86 (K86I). These mutations are predicted to produce a dominant negative product. Line 19 was generated. (J:142787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142787 Hirotani S, et al., Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res. 2007 Nov 26;101(11):1164-74
• All: 2 reference(s)