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Scyl1tm1Spel
Targeted Allele Detail
Nomenclature
Symbol: Scyl1tm1Spel
Name: SCY1-like 1 (S. cerevisiae); targeted mutation 1, Stephane Pelletier
MGI ID: MGI:5469959
Synonyms: Scyl1fl
Gene: Scyl1  Location: Chr19:5758422-5771414 bp, - strand  Genetic Position: Chr19, 4.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192445
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted downstream of exon 1. A FLAG-tag and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 17. Cre-mediated recombination removed exons 2 through 17 and the neo cassette. (J:192445)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scyl1 Mutation:  4 strains or lines available
References
Original:  J:192445 Pelletier S, et al., An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43. J Neurosci. 2012 Nov 21;32(47):16560-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory