About   Help   FAQ
Targeted Allele Detail
Symbol: Pik3catm1Gne
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Genentech
MGI ID: MGI:5469577
Synonyms: Pik3cae20mwt
Gene: Pik3ca  Location: Chr3:32397671-32466107 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:193377
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Single point mutation
Mutation detailsA loxP site was in upstream of the wild-type exon 20, which was followed by a polyadenylation sequence, an FRT-flanked neo cassette, 4x transcriptional STOP, a loxP site and a modified exon 20. The modified exon 20 contained an A to G transition results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination is required to remove the wild-type exon 20 and allow for expression of the modified exon 20. (J:193377)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  42 strains or lines available
Original:  J:193377 Yuan W, et al., Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations. Oncogene. 2013 Jan 17;32(3):318-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory