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Targeted Allele Detail
Symbol: Pik3catm1Gne
Name: phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; targeted mutation 1, Genentech
MGI ID: MGI:5469577
Synonyms: Pik3cae20mwt
Gene: Pik3ca  Location: Chr3:32397671-32466107 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:193377
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Single point mutation
Mutation detailsA loxP site was in upstream of the wild-type exon 20, which was followed by a polyadenylation sequence, an FRT-flanked neo cassette, 4x transcriptional STOP, a loxP site and a modified exon 20. The modified exon 20 contained an A to G transition results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination is required to remove the wild-type exon 20 and allow for expression of the modified exon 20. (J:193377)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  15 strains or lines available
Original:  J:193377 Yuan W, et al., Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations. Oncogene. 2013 Jan 17;32(3):318-26
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory