Dot1l^tm1.1Saam
Targeted Allele Detail

Summary

• Symbol: Dot1l^tm1.1Saam
• Name: DOT1 like histone lysine methyltransferase; targeted mutation 1.1, Scott Armstrong
• MGI ID: MGI:5468988
• Synonyms: Dot1l^f
• Gene: Dot1l Location: Chr10:80591040-80631295 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dot1l^tm1.1Saam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193161
• Parent Cell Line: CJ9 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked puro cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the puro cassette and left exon 5 floxed. (J:193161)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dot1l Mutation: 69 strains or lines available

References

• Original: J:193161 Bernt KM, et al., MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 2011 Jul 12;20(1):66-78
• All: 10 reference(s)