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Tg(CAG-Diaph3)771Lesp
Transgene Detail
Nomenclature
Symbol: Tg(CAG-Diaph3)771Lesp
Name: transgene insertion 771, Marci Lesperance
MGI ID: MGI:5468143
Synonyms: Tg(CAG-Diap3)771Lesp
Transgene: Tg(CAG-Diaph3)771Lesp  Location: unknown  
The stereocilia of Tg(CAG-Diaph3)771Lesp/0 and Tg(CAG-Diap3)924Lesp/0 mice become progressively abnormal from 4 to 24 weeks of age

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-Diaph3)771Lesp expresses 1 gene
 
Mutation detailsThe insertion vector was approximately 7 kb, containing the CAG promoter and the Diaph3 complete coding sequence. Genotyping by PCR revealed that 10 of 83 potential transgenic founders had integrated the transgene. Five founders transmitted the transgene with offspring born in expected Mendelian ratios. Lines 771 and 924 exhibited hearing loss within the first 16 weeks of life in the F1 generation as detected by auditory brainstem response (ABR) testing and were selected for further analysis. (J:193237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:193237 Schoen CJ, et al., Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness. PLoS One. 2013;8(2):e56520
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory