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Slc6a13tm1.2Ncd
Targeted Allele Detail
Summary
Symbol: Slc6a13tm1.2Ncd
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 13; targeted mutation 1.2, NC Danbolt
MGI ID: MGI:5466690
Synonyms: GAT2-fKO
Gene: Slc6a13  Location: Chr6:121277247-121314680 bp, + strand  Genetic Position: Chr6, 57.22 cM, cytoband F1
Alliance: Slc6a13tm1.2Ncd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191581
Parent Cell Line:  D1 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 5 through 7. This allele lacks the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the brain. (J:191581)
Generation of the Slc6a13tm1.1Ncd and Slc6a13tm1.2Ncd alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a13 Mutation:  46 strains or lines available
References
Original:  J:191581 Zhou Y, et al., Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem. 2012 Oct 12;287(42):35733-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory