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Targeted Allele Detail
Symbol: Esr1tm4.2Ksk
Name: estrogen receptor 1 (alpha); targeted mutation 4.2, Kenneth S Korach
MGI ID: MGI:5465426
Synonyms: Ex3alphaERKO, Ex3-ERKO
Gene: Esr1  Location: Chr10:4611989-5005633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:191182
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette and exon 3 were subsequently removed from properly targeted mice by cre excision. (J:191182)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  14 strains or lines available
Original:  J:191182 Hewitt SC, et al., Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J. 2010 Dec;24(12):4660-7
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory