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Targeted Allele Detail
Symbol: Srgap3tm1.1Zi
Name: SLIT-ROBO Rho GTPase activating protein 3; targeted mutation 1.1, Dusan Bartsch
MGI ID: MGI:5465281
Gene: Srgap3  Location: Chr6:112717971-112947266 bp, - strand  Genetic Position: Chr6, 52.54 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:192388
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 3 was replaced with a modified one with a premature stop codon. This mutation resembled the breakpoint of the t(3; X)(p25;p11) translocation. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of the modified exon 3. Western blot anlaysis confirmed the absence of protein expression in the adult cortex. (J:192388)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srgap3 Mutation:  4 strains or lines available
Original:  J:192388 Waltereit R, et al., Srgap3(-)/(-) mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. FASEB J. 2012 Nov;26(11):4418-28
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory