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Nlrp3tm1Bhk
Targeted Allele Detail
Nomenclature
Symbol: Nlrp3tm1Bhk
Name: NLR family, pyrin domain containing 3; targeted mutation 1, Beverly H Koller
MGI ID: MGI:5465108
Gene: Nlrp3  Location: Chr11:59541569-59566955 bp, + strand  Genetic Position: Chr11, 37.73 cM, cytoband B1.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189777
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The entire coding sequence was replaced with a neo cassette. (J:189777)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlrp3 Mutation:  40 strains or lines available
References
Original:  J:189777 Kovarova M, et al., NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol. 2012 Aug 15;189(4):2006-16
All:  70 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory