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Foxn1nu-2J
Spontaneous Allele Detail
Nomenclature
Symbol: Foxn1nu-2J
Name: forkhead box N1; nude 2 Jackson
MGI ID: MGI:5464997
Gene: Foxn1  Location: Chr11:78248403-78277384 bp, - strand  Genetic Position: Chr11, 46.74 cM
Mutation
origin
Strain of Origin:  B6.SJL-Ptprca Pepcb/BoyJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThis spontaneous mutation, which fails to complement the original nude mutation, has a 7 nucleotide deletion encompassing chromosome 11 nucleotides 78,371,200-206 (GRCm38). This causes a frameshift that leads to the introduction of 186 novel amino acids beginning at residue 114 and then an early termination codon within the forkhead DNA binding domain. (J:192383, J:222308)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:  88 strains or lines available
References
Original:  J:192383 Harris BS, et al., Nude 2 Jackson: A new spontaneous mutation in Foxn1. MGI Direct Data Submission. 2013;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory