Meis1^tm2Ngc
Targeted Allele Detail

Summary

• Symbol: Meis1^tm2Ngc
• Name: Meis homeobox 1; targeted mutation 2, Neal G Copeland
• MGI ID: MGI:5464994
• Synonyms: Meis1^fl, Meis1^flox
• Gene: Meis1 Location: Chr11:18830428-18968992 bp, - strand Genetic Position: Chr11, 11.11 cM
• Alliance: Meis1^tm2Ngc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192126
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT- and loxP site flanked neo cassette was inserted downstream of exon 8. Flp-mediated recombination removed the neo cassette and left exon 8 floxed. (J:192126, J:192624)

Expression

In Mice Carrying this Mutation:

1 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Meis1 Mutation: 46 strains or lines available

References

• Original: J:192126 Kocabas F, et al., Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. Blood. 2012 Dec 13;120(25):4963-72
• All: 16 reference(s)