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Ndufs4tm1Capt
Targeted Allele Detail
Nomenclature
Symbol: Ndufs4tm1Capt
Name: NADH dehydrogenase (ubiquinone) Fe-S protein 4; targeted mutation 1, Carl A Pinkert
MGI ID: MGI:5464892
Gene: Ndufs4  Location: Chr13:114287795-114388094 bp, - strand  Genetic Position: Chr13, 64.12 cM, cytoband D2.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192154
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsA point mutant construct with a floxed neo cassette resulted in truncation of the last exon prior to a conserved 10 to 15 amino acid sequence. Western blot analysis confirmed reduced expression of a truncated protein in heterozygous mice. (J:192154)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndufs4 Mutation:  18 strains or lines available
Notes
ES cell = PC1 (129S6/SvEvTac)

References
Original:  J:192154 Ingraham CA, et al., NDUFS4: creation of a mouse model mimicking a Complex I disorder. Mitochondrion. 2009 Jun;9(3):204-10
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory