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Tg(CAG-Diap3)924Lesp
Transgene Detail
Nomenclature
Symbol: Tg(CAG-Diap3)924Lesp
Name: transgene insertion 924, Marci Lesperance
MGI ID: MGI:5462250
Transgene: Tg(CAG-Diap3)924Lesp  Location: unknown  
The stereocilia of Tg(CAG-Diaph3)771Lesp/0 and Tg(CAG-Diap3)924Lesp/0 mice become progressively abnormal from 4 to 24 weeks of age

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-Diap3)924Lesp expresses 1 gene
 
Mutation detailsA transgenic construct contains the mouse gene under the control of the CAG, CMV enhancer/chicken beta-actin, promoter. Founder line 924 was subsequently established. (J:193237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:193237 Schoen CJ, et al., Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness. PLoS One. 2013;8(2):e56520
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory