Thbd^{tm1.1(THBD)Sltz}
Targeted Allele Detail

Summary

• Symbol: Thbd^{tm1.1(THBD)Sltz}
• Name: thrombomodulin; targeted mutation 1.1, Steven R Lentz
• MGI ID: MGI:5462218
• Synonyms: Hthm
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^{tm1.1(THBD)Sltz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence was replaced with the corresponding human sequence with a C to T transistion that results in the amino acid change of valine for alanine at position 455 (A455T). Cre-mediated recombination removed the floxed neo cassette that was inserted into the 3' UTR. (J:191461)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 23 strains or lines available

References

• Original: J:191461 Raife TJ, et al., Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2509-17
• All: 1 reference(s)