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Men1tm1Rvt
Targeted Allele Detail
Nomenclature
Symbol: Men1tm1Rvt
Name: multiple endocrine neoplasia 1; targeted mutation 1, Rajesh V Thakker
MGI ID: MGI:5461232
Gene: Men1  Location: Chr19:6334979-6340891 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191261
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A floxed neo cassette replaced exons 1 and 2. (J:191261)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  17 strains or lines available
References
Original:  J:191261 Harding B, et al., Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Endocr Relat Cancer. 2009 Dec;16(4):1313-27
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory