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Targeted Allele Detail
Symbol: Fgd4tm1.1Ics
Name: FYVE, RhoGEF and PH domain containing 4; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5460858
Synonyms: Fgd4-
Gene: Fgd4  Location: Chr16:16416917-16600549 bp, - strand  Genetic Position: Chr16, 10.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:190437
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe loxP flanked exon 4 was removed via cre-mediated recombination, generating a premature stop codon in exon 5 because of a frame shift. Western blot analysis confirmed lack of protein expression in sciatic nerve. (J:190437)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgd4 Mutation:  44 strains or lines available
Original:  J:190437 Horn M, et al., Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells. Brain. 2012 Dec;135(Pt 12):3567-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory