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Transgene Detail
Symbol: Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa
Name: transgene insertion, Timothy J Sargeant
MGI ID: MGI:5451192
Synonyms: P8SYN (+), SYNTg
Transgene: Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa  Location: unknown  
Doxycycline treatment of Hexbtm1Rlp/Hexbtm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 and Hexbtm1Rlp/Hexbtm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 mice induces storage of glycolipids

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6 x CBA
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Transactivator)
Mutation:    Insertion
Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa expresses 1 gene
Mutation detailsThe human SYN1 promoter drives expression of the tet-transactivator from the pTet-off advanced plasmid and tet responsive element (TRE-tight) drives expression of a full lenght mouse Hexb cDNA. Expression is seen only in the nervous tissue. In the cerebral cortex the tet-transactivator transcript is strongly expressed in layer 6b neurons. (J:190450)
Schematic of the Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa transgene construct
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:190450 Sargeant TJ, et al., Characterization of inducible models of Tay-Sachs and related disease. PLoS Genet. 2012 Sep;8(9):e1002943
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory