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Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa
Transgene Detail
Nomenclature
Symbol: Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa
Name: transgene insertion, Timothy J Sargeant
MGI ID: MGI:5451190
Synonyms: HexTg, P8Hex (+)
Transgene: Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa  Location: unknown  
Localized glycolipid storage and microgliosis in Hexbtm1Rlp/Hexbtm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 mice

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Transactivator)
Mutation:    Insertion
 
Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa expresses 1 gene
 
Mutation detailsThe proximal murine Hexb promoter (330 bp) drives expression of the tet-transactivator from the pTet-off advanced plasmid and tet responsive element (TRE-tight) drives expression of a full length mouse Hexb cDNA. Expression is seen only in the nervous tissue, skin and skeletal muscle. In the cerebral cortex expression of the tet-transactivator transcript is evenly distributed through the cortex. (J:190450)
Schematic of the Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa transgene construct
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:190450 Sargeant TJ, et al., Characterization of inducible models of Tay-Sachs and related disease. PLoS Genet. 2012 Sep;8(9):e1002943
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory