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Fgfr2tm3Ewj
Targeted Allele Detail
Nomenclature
Symbol: Fgfr2tm3Ewj
Name: fibroblast growth factor receptor 2; targeted mutation 3, Ethylin Wang Jabs
MGI ID: MGI:5450938
Synonyms: Fgfr2Y394C
Gene: Fgfr2  Location: Chr7:130162451-133123350 bp, - strand  Genetic Position: Chr7, 73.19 cM
Fgfr2tm3Ewj/Fgfr2+ mice have cutis gyrata, acanthosis, skull synostosis, and other abnormalities

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190491
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation details
Generation of the Fgfr2tm3Ewj allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  18 strains or lines available
References
Original:  J:190491 Wang Y, et al., p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. J Clin Invest. 2012 Jun 1;122(6):2153-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory