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Nmnat1tm1.2Lcon
Targeted Allele Detail
Nomenclature
Symbol: Nmnat1tm1.2Lcon
Name: nicotinamide nucleotide adenylyltransferase 1; targeted mutation 1.2, Laura Conforti
MGI ID: MGI:5450825
Gene: Nmnat1  Location: Chr4:149467572-149485202 bp, - strand  Genetic Position: Chr4, 79.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190793
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the neo cassette and exons 1 and 2. Western blot analysis confirmed the reduction in protein expression in skeletal muscle from heterozygotes. (J:190793)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nmnat1 Mutation:  14 strains or lines available
References
Original:  J:190793 Conforti L, et al., Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration. FEBS J. 2011 Aug;278(15):2666-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory