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Targeted Allele Detail
Symbol: Fras1tm1.2Pjsc
Name: Fraser extracellular matrix complex subunit 1; targeted mutation 1.2, Peter J Scambler
MGI ID: MGI:5449389
Synonyms: Fras1delta2
Gene: Fras1  Location: Chr5:96373955-96784728 bp, + strand  Genetic Position: Chr5, 47.29 cM
Hemorrhagic blistering and absence of kidney in Fras1tm1.2Pjsc/Fras1tm1.2Pjsc mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:190659
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination removed exon 2 and the neo cassette. (J:190659)
Generation of the Fras1tm1.1Pjsc and Fras1tm1.2Pjsc alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fras1 Mutation:  133 strains or lines available
Original:  J:190659 Pitera JE, et al., Generation of mice with a conditional null fraser syndrome 1 (Fras1) allele. Genesis. 2012 Dec;50(12):892-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory