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Mir378atm1.1Eno
Targeted Allele Detail
Nomenclature
Symbol: Mir378atm1.1Eno
Name: microRNA 378a; targeted mutation 1.1, Eric N Olson
MGI ID: MGI:5448834
Gene: Mir378a  Location: Chr18:61530906-61530971 bp, - strand  Genetic Position: Chr18, 34.62 cM
Mir378atm1.1Eno/Mir378atm1.1Eno mice are resistant to high-fat diet-induced obesity

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190154
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe microRNA sequence was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. qRT-PCR confirmed the absence of transcript expression. Western blot analysis confirmed normal protein expression of the host gene. (J:190154)
Generation of the Mir378atm1.1Eno allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir378a Mutation:  4 strains or lines available
References
Original:  J:190154 Carrer M, et al., Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15330-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory