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Targeted Allele Detail
Symbol: Kdm6atm1.2Kaig
Name: lysine (K)-specific demethylase 6A; targeted mutation 1.2, Kai Ge
MGI ID: MGI:5448825
Synonyms: UTX-
Gene: Kdm6a  Location: ChrX:18162575-18279936 bp, + strand  Genetic Position: ChrX, 13.45 cM
Neural tube closure, cardiac development and hematopoiesis defects in Kdm6atm1.2Kaig/Kdm6atm1.2Kaig females

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:190157
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination removed the modified exon 24. Western blot analysis confirmed the absence of protein expression in embryonic stem cells. (J:190157)
Generation of the Kdm6atm1.2Kaig allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  38 strains or lines available
Original:  J:190157 Wang C, et al., UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory