Kdm6a^tm1.1Kaig
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1.1Kaig
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1.1, Kai Ge
• MGI ID: MGI:5448754
• Synonyms: UTX^flox
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1.1Kaig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 24. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 24. Flp-mediated recombination removed the neo cassette inserted downstream of the modified exon 24. The modified exon 24 remains floxed. (J:190157)

Generation of the Kdm6a^tm1.2Kaig allele

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 38 strains or lines available

References

• Original: J:190157 Wang C, et al., UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
• All: 16 reference(s)