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Tg(Col11a2-Npr2*)28Keoz
Transgene Detail
Nomenclature
Symbol: Tg(Col11a2-Npr2*)28Keoz
Name: transgene insertion 28, Keiichi Ozono
MGI ID: MGI:5448404
Transgene: Tg(Col11a2-Npr2*)28Keoz  Location: unknown  
Skeletal abnormalities in Tg(Col11a2-Npr2*)28Keoz/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Col11a2-Npr2*)28Keoz expresses 1 gene
 
Mutation detailsThe promoter and intronic enhancer of Col11a2 drives expression of a mutant version of Npr2 (p.Val883Met) in chondrocytes. Expression of Npr2 mRNA was increased 5.1 fold in costal cartilage. (J:189658)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:189658 Miura K, et al., An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS One. 2012;7(8):e42180
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory