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Chit1tm1Eli
Targeted Allele Detail
Summary
Symbol: Chit1tm1Eli
Name: chitinase 1; targeted mutation 1, Jack A Elias
MGI ID: MGI:5447948
Gene: Chit1  Location: Chr1:134038980-134079278 bp, + strand  Genetic Position: Chr1, 58.12 cM, cytoband E4
Alliance: Chit1tm1Eli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189872
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced exons 1 through 5. ELISA confirmed the absence of protein expression in the serum. (J:189872)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chit1 Mutation:  32 strains or lines available
References
Original:  J:189872 Lee CG, et al., Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-beta1 signaling. J Immunol. 2012 Sep 1;189(5):2635-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory