Havcr2^tm1Bmed
Targeted Allele Detail

Summary

• Symbol: Havcr2^tm1Bmed
• Name: hepatitis A virus cellular receptor 2; targeted mutation 1, Benjamin D Medoff
• MGI ID: MGI:5447924
• Synonyms: Tim3^mut
• Gene: Havcr2 Location: Chr11:46345762-46372082 bp, + strand Genetic Position: Chr11, 27.9 cM
• Alliance: Havcr2^tm1Bmed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette was inserted into exon 7 encoding the cytoplasmic domain (resulting in the deletion of amino acids 263 to 280). QPCR comfirmed reduced transcript expression of the portion encoding the cytoplasmic domain in splenocytes. (J:189839)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Havcr2 Mutation: 32 strains or lines available

References

• Original: J:189839 Cho JL, et al., Enhanced Tim3 activity improves survival after influenza infection. J Immunol. 2012 Sep 15;189(6):2879-89
• All: 3 reference(s)