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Atp7atm1.1Mjp
Targeted Allele Detail
Nomenclature
Symbol: Atp7atm1.1Mjp
Name: ATPase, Cu++ transporting, alpha polypeptide; targeted mutation 1.1, Michael J Petris
MGI ID: MGI:5447640
Synonyms: Atp7afl
Gene: Atp7a  Location: ChrX:106027276-106124926 bp, + strand  Genetic Position: ChrX, 47.36 cM
Patches of hypopigmentation in coats of Atp7atm1.1Mjp/Atp7a+ Cldn6tm1(cre)Dkwu/Cldn6+ females

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 11. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:189931)
Generation of the Atp7atm1.1Mjp allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp7a Mutation:  69 strains or lines available
References
Original:  J:189931 Wang Y, et al., Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis. PLoS One. 2012;7(8):e43039
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory