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Scn1atm2.1Wac
Targeted Allele Detail
Nomenclature
Symbol: Scn1atm2.1Wac
Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 2.1, William A Catterall
MGI ID: MGI:5447489
Gene: Scn1a  Location: Chr2:66270781-66440840 bp, - strand  Genetic Position: Chr2, 39.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189897
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Schematic representation of the targeting construct used to generate the Scn1atm2.1Wac allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn1a Mutation:  5 strains or lines available
References
Original:  J:189897 Cheah CS, et al., Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory