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Tg(BCL2/IGH)#Jcre
Transgene Detail
Nomenclature
Symbol: Tg(BCL2/IGH)#Jcre
Name: transgene insertion, John C Reed
MGI ID: MGI:5447039
Synonyms: BCL-2-tg
Transgene: Tg(BCL2/IGH)#Jcre  Location: unknown  
Transgene
origin
Strain of Origin:  (SWR/J x SJL/J)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(BCL2/IGH)#Jcre expresses 2 genes
 
Mutation detailsA human genomic BCL2/IGH fusion minigene was used for the transgene. This construct represents a translocation mutation, t(14:18), found in human follicular B cell lymphomas. Line 2 (expression preferentially in the spleen, lymph nodes and thymus) and 6 (expression preferentially in the thymus, lymph node and spleen) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:131936)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:131936 Katsumata M, et al., Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11376-80
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory