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B3gnt6tm1Lx
Targeted Allele Detail
Nomenclature
Symbol: B3gnt6tm1Lx
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase); targeted mutation 1, Lijun Xia
MGI ID: MGI:5447022
Synonyms: C3GnT-
Gene: B3gnt6  Location: Chr7:98192415-98199475 bp, - strand  Genetic Position: Chr7, 53.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123826
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ and neo cassette replaced exon 2. Enzymatic assay confirmed the absence of activity in the colon and ileum. (J:123826)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any B3gnt6 Mutation:  7 strains or lines available
References
Original:  J:123826 An G, et al., Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med. 2007 Jun 11;204(6):1417-29
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory