About   Help   FAQ
b2b1941Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b1941Clo
Name: Mutant line 1941; Bench to Bassinet Program (B2B/CVDC), mutation 1941 Cecilia Lo
MGI ID: MGI:5446162
Synonyms: Unicorn
Gene: b2b1941Clo  Location: unknown  
Mutant 1941-003-2 (E15.5) shows persistent truncus arteriosus (PTA) and high aortic arch

Show the 23 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. Additional incidental mutations were detected in sequencing for the causative mutation, b2b1941Clo, and may be present in stocks carrying this mutation.
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1941Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiac phenotype: Persistent truncus arteriousus (PTA), pulmonary atresia (PA), transposition of the great arteries (d-TGA), atrioventricular septal defect (AVSD), major aortopulmonary collateral artery (MAPCA), aortic arch anomalies and vascular ring
Noncardiac phenotype: Cleft palate, micrognathia, micropthalmia, thymus aplasia, tracheoesophageal fistula, hydronephrosis, duplex kidney

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0541 Truncus arteriosus type 4a
0700 D-loop transposition of the great arteries
1000 Pulmonary atresia congenital
1100 Atrioventricular canal (endocardial cushion defect)
2760 Vascular ring
2771 Multiple major aortopulmonary collateral arteries (mapcas)
4202 Tracheoesophageal fistula
4502 Hydronephrosis
4609 Velocardiofacial syndrome
4610 DiGeorge syndrome
4876 Cleft palate
4877 Microphthalmia

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory