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Targeted Allele Detail
Symbol: Nlrc4tm1Gne
Name: NLR family, CARD domain containing 4; targeted mutation 1, Genentech
MGI ID: MGI:5446022
Synonyms: Nlrc4F
Gene: Nlrc4  Location: Chr17:74733254-74766140 bp, - strand  Genetic Position: Chr17, 45.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:189256
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThree FLAG-tags were inserted into exon 9 ahead of the translation termination site. An FRT-flanked neo cassette was inserted upstream of the modified exon 9. (J:189256)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrc4 Mutation:  46 strains or lines available
Original:  J:189256 Qu Y, et al., Phosphorylation of NLRC4 is critical for inflammasome activation. Nature. 2012 Oct 25;490(7421):539-42
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory