Nlrc4^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Nlrc4^tm1Gne
• Name: NLR family, CARD domain containing 4; targeted mutation 1, Genentech
• MGI ID: MGI:5446022
• Synonyms: Nlrc4^F
• Gene: Nlrc4 Location: Chr17:74733254-74766140 bp, - strand Genetic Position: Chr17, 45.64 cM
• Alliance: Nlrc4^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189256
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Three FLAG-tags were inserted into exon 9 ahead of the translation termination site. An FRT-flanked neo cassette was inserted upstream of the modified exon 9. (J:189256)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc4 Mutation: 67 strains or lines available

References

• Original: J:189256 Qu Y, et al., Phosphorylation of NLRC4 is critical for inflammasome activation. Nature. 2012 Oct 25;490(7421):539-42
• All: 7 reference(s)