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Raf1tm2.1Ara
Targeted Allele Detail
Nomenclature
Symbol: Raf1tm2.1Ara
Name: v-raf-leukemia viral oncogene 1; targeted mutation 2.1, Toshiyuki Araki
MGI ID: MGI:5445964
Synonyms: Raf1D486N
Gene: Raf1  Location: Chr6:115618067-115676635 bp, - strand  Genetic Position: Chr6, 53.62 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189143
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCr)F1
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Raf1 Mutation:  88 strains or lines available
References
Original:  J:189143 Wu X, et al., Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Mol Cell Biol. 2012 Oct;32(19):3872-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory