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Thbdtm1.1Hlwu
Targeted Allele Detail
Nomenclature
Symbol: Thbdtm1.1Hlwu
Name: thrombomodulin; targeted mutation 1.1, Hua-Lin Wu
MGI ID: MGI:5445362
Synonyms: TMflox
Gene: Thbd  Location: Chr2:148404471-148408188 bp, - strand  Genetic Position: Chr2, 73.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188879
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe coding exon was flanked by a loxP site and an FRT-flanked neo cassette with a 3' loxP site. Flp-mediated recombination remvoed the neo cassette and left the gene floxed. (J:188879)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:  0 strains or lines available
References
Original:  J:188879 Ma CY, et al., Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol. 2012 Jun 15;188(12):6328-37
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory