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b2b1432Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b1432Clo
Name: Mutant line 1432; Bench to Bassinet Program (B2B/CVDC), mutation 1432 Cecilia Lo
MGI ID: MGI:5445346
Synonyms: Hermey
Gene: b2b1432Clo  Location: unknown  
Mutant 1432-005-LA displays slightly narrow aorta and hypoplastic left ventricle.

Show the 13 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1432Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any b2b1432Clo Mutation:  0 strains or lines available
Notes
Summative Diagnosis:
Cardiovascular phenotype: Hypoplastic left ventricle, hypoplastic mitral valve, and dysplastic aortic valve with critical aortic stenosis
Noncardiovascular phenotype: Short snout

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0300 Hypoplastic left heart syndrome
1400 Aortic valve abnormality
1410 Aortic stenosis
1515 Hypoplastic mitral valve
1811 Hypoplastic left ventricle (subnormal cavity volume)
4906 Non-cardiac abnormality

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory