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Gucy1b2tm2Mom
Targeted Allele Detail
Nomenclature
Symbol: Gucy1b2tm2Mom
Name: guanylate cyclase 1, soluble, beta 2; targeted mutation 2, Peter Mombaerts
MGI ID: MGI:5444154
Synonyms: Gucy1b2-D-IRES-tauGFP, Gucy1b2-KO
Gene: Gucy1b2  Location: Chr14:62392676-62456289 bp, - strand  Genetic Position: Chr14, 33.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235858
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately 4.3 kb of DNA encoding the catalytic domain, spanning from partway through exon 12 to partway through of exon 15, was deleted, a stop codon and AscI site was generated in the middle of exon 12, and an IRES-tauGFP-pA ACNF cassette was inserted into the AscI site thus creating a null allele with GFP reporter. (J:235858)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gucy1b2 Mutation:  24 strains or lines available
References
Original:  J:235858 Bleymehl K, et al., A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium. Neuron. 2016 Dec 21;92(6):1196-1203
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory