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Rspo3tm1.1Jcob
Targeted Allele Detail
Nomenclature
Symbol: Rspo3tm1.1Jcob
Name: R-spondin 3; targeted mutation 1.1, John Cobb
MGI ID: MGI:5443941
Synonyms: Rspo3F
Gene: Rspo3  Location: Chr10:29329102-29411863 bp, - strand  Genetic Position: Chr10, 16.64 cM, cytoband A4
Rspo2ftls/Rspo2ftls Rspo3tm1.1Jcob/Rspo3tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188812
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:188812)
Generation of the Rspo3tm1.1Jcob and Rspo3tm1.2Jcob alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rspo3 Mutation:  7 strains or lines available
References
Original:  J:188812 Neufeld S, et al., A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development. Genesis. 2012 Oct;50(10):741-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory