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Foxc1tm1.1Tsku
Targeted Allele Detail
Nomenclature
Symbol: Foxc1tm1.1Tsku
Name: forkhead box C1; targeted mutation 1.1, Tsutomu Kume
MGI ID: MGI:5443919
Synonyms: Foxc1delta
Gene: Foxc1  Location: Chr13:31806691-31810643 bp, + strand  Genetic Position: Chr13, 13.52 cM
Hydrocephalus and eye abnormalities in Foxc1tm1.1Tsku/Foxc1tm1.1Tsku fetuses

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188816
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the coding sequence from Foxc1tm1Tsku. RT-PCR confirmed the absence of transcript expression in embryos. (J:188816)
Generation of the Foxc1tm1Tsku and Foxc1tm1.1Tsku alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxc1 Mutation:  10 strains or lines available
References
Original:  J:188816 Sasman A, et al., Generation of conditional alleles for Foxc1 and Foxc2 in mice. Genesis. 2012 Oct;50(10):766-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory