Tph2^tm1.1Pasq
Targeted Allele Detail

Summary

• Symbol: Tph2^tm1.1Pasq
• Name: tryptophan hydroxylase 2; targeted mutation 1.1, Massimo Pasqualetti
• MGI ID: MGI:5442737
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^tm1.1Pasq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188987
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One hundred and five nucleotides downstream of the first ATG codon were replaced by a cDNA for EGFP and an FRT flanked neomycin selection cassette. The neo selection cassette was subsequently removed by flp recombinase expression. (J:188987)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 41 strains or lines available

References

• Original: J:188987 Migliarini S, et al., Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation. Mol Psychiatry. 2013 Oct;18(10):1106-18
• All: 6 reference(s)