Prkcsh^tm1Som
Targeted Allele Detail

Summary

• Symbol: Prkcsh^tm1Som
• Name: protein kinase C substrate 80K-H; targeted mutation 1, Stefan Somlo
• MGI ID: MGI:5442170
• Synonyms: Prkcsh^flox
• Gene: Prkcsh Location: Chr9:21914284-21925541 bp, + strand Genetic Position: Chr9, 8.04 cM
• Alliance: Prkcsh^tm1Som page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 6 and 7 were floxed and an FRT-flanked neo cassette was inserted into IVS7. (J:188763)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcsh Mutation: 27 strains or lines available

References

• Original: J:188763 Fedeles SV, et al., A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet. 2011 Jul;43(7):639-47
• All: 2 reference(s)