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b2b1594Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b1594Clo
Name: Mutant line 1594; Bench to Bassinet Program (B2B/CVDC), mutation 1594 Cecilia Lo
MGI ID: MGI:5442115
Synonyms: Zombie
Gene: b2b1594Clo  Location: unknown  
Mutant 1594-004-NA shows cleft palate

Show the 11 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1594Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1594Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiac phenotype: Biventricular hypertrophy, aortic arch anomalies such as vascular ring
Non-cardiac phenotype: Cleft palate, microganthia, necrotic gut, short digits with oligodactyly/syndactyly, and club foot

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
2705 Aortic arch abnormal branching
2760 Vascular ring
4163 Micrognathia
4171 Clubfoot (talipes)
4174 Syndactyly
4876 Cleft palate
7505 Biventricular hypertrophy

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory