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Rr20tm1.1Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Rr20tm1.1Vlcg
Name: regulatory region 20; targeted mutation 1.1, Velocigene
MGI ID: MGI:5441845
Synonyms: ECR5-
Gene: Rr20  Location: unknown  Genetic Position: Chr11, Syntenic
Higher bone mass in Rr20tm1.1Vlcg/Rr20tm1.1Vlcg and Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188586
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation details
Rr20tm1.1Vlcg/Rr20tm1.1Vlcg mice have HBM due to reduced number of Sost-expressing osteocytes
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr20 Mutation:  0 strains or lines available
References
Original:  J:188586 Collette NM, et al., Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14092-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory