Atp6v0a4tm1.1Fekf
Targeted Allele Detail
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Symbol: |
Atp6v0a4tm1.1Fekf |
Name: |
ATPase, H+ transporting, lysosomal V0 subunit A4; targeted mutation 1.1, Fiona E Karet Frankl |
MGI ID: |
MGI:5441584 |
Gene: |
Atp6v0a4 Location: Chr6:38025418-38101521 bp, - strand Genetic Position: Chr6, 17.5 cM, cytoband B1
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Alliance: |
Atp6v0a4tm1.1Fekf page
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Small size and hydronephrotic kidney in Atp6v0a4tm1.1Fekf/Atp6v0a4tm1.1Fekf mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:188593
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2 - 4 were replaced with a nuclear localizing signal betagal coding sequence and a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the pgk-neo cassette. Western blot analysis of total kidney lysates from homozygous mice confirmed the absence of protein expression. LacZ expression is detected in the metanephros, ear, and nasal epithelium at E12.5 and in the developing bone at E13.5.
(J:188593)
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Generation of the Atp6v0a4tm1.1Fekf allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Atp6v0a4 Mutation: |
31 strains or lines available
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Original: |
J:188593 Norgett EE, et al., Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13775-80 |
All: |
3 reference(s) |
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