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Tg(Ins2-Tag*,-flpe)#Gne
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-Tag*,-flpe)#Gne
Name: transgene insertion, Genentech
MGI ID: MGI:5441546
Synonyms: RIP-TbetaAg
Transgene: Tg(Ins2-Tag*,-flpe)#Gne  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of 2 co-injected constructs. The first construct contains the rat insulin promoter followed by an SV40 T antigen in which the two exons are interrupted by an FRT flanked beta-globin intron. The second construct contains he rat insulin promoter followed by a flpe gene. Recombination and expression of the transgene is seen in the pancreas. Absence of recombination in the liver and spleen was confirmed by PCR analysis. (J:187012)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ins2     Summary of all recombinase alleles driven by Ins2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:188693 Bagri A, et al., Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy. Clin Cancer Res. 2010 Aug 1;16(15):3887-900
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/08/2020
MGI 6.15
The Jackson Laboratory