Tg(Igkv3-5*-MYC)#Plbe
Transgene Detail

Summary

• Symbol: Tg(Igkv3-5*-MYC)#Plbe
• Name: transgene insertion, P Leif Bergsagel
• MGI ID: MGI:5441311
• Synonyms: VkMYC, Vk*MYC, Vk*MYCDLoxP
• Transgene: Tg(Igkv3-5*-MYC)#Plbe Location: unknown
• Alliance: Tg(Igkv3-5*-MYC)#Plbe page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igkv3-5*-MYC)#Plbe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector MN894515 without stop codon). The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. Lines 11 and 24 (20 and 8 copies of the transgene, respectively, inserted chr11:6965780-7030487 and chr17:91535994-91546658, mm39, respectively) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:99667)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Igkv3-5*-MYC)#Plbe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131912 Chesi M, et al., AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008 Feb;13(2):167-80
• All: 17 reference(s)