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Tg(Igkv3-5*-MYC)#Plbe
Transgene Detail
Nomenclature
Symbol: Tg(Igkv3-5*-MYC)#Plbe
Name: transgene insertion, P Leif Bergsagel
MGI ID: MGI:5441311
Synonyms: Vk*MYC
Transgene: Tg(Igkv3-5*-MYC)#Plbe  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igkv3-5*-MYC)#Plbe expresses 1 gene
 
Mutation detailsThe mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. Lines 11 and 24 (20 and 8 copies of the transgene, respectively) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:99667)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:131912 Chesi M, et al., AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008 Feb;13(2):167-80
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory