Relb^tm1.1Fwei
Targeted Allele Detail

Summary

• Symbol: Relb^tm1.1Fwei
• Name: avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1.1, Falk Weih
• MGI ID: MGI:5441212
• Synonyms: Relb^fl
• Gene: Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
• Alliance: Relb^tm1.1Fwei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169863
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: By homologous recombination in ES cells, the targeting vector inserted a floxed neomycin (neo) resistance cassette into the 4th intron of the Relb gene and a single loxP site into 184 bp upstream of exon 4. The neo cassette was deleted by transient transfection of a plasmid (pMC-cre) expressing Cre recombinase in the ES cells, resulting in the allele with the exon 4 being floxed. (J:169863, J:188293, J:270571)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Relb Mutation: 32 strains or lines available

References

• Original: J:169863 Powolny-Budnicka I, et al., RelA and RelB Transcription Factors in Distinct Thymocyte Populations Control Lymphotoxin-Dependent Interleukin-17 Production in gammadelta T Cells. Immunity. 2011 Mar 25;34(3):364-74
• All: 12 reference(s)