Gjb2^{tm3.2(Gjb1)Kwi}
Targeted Allele Detail

Summary

• Symbol: Gjb2^{tm3.2(Gjb1)Kwi}
• Name: gap junction protein, beta 2; targeted mutation 3.2, Klaus Willecke
• MGI ID: MGI:5441203
• Synonyms: Cx26^Cx32
• Gene: Gjb2 Location: Chr14:57336059-57342159 bp, - strand Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
• Alliance: Gjb2^{tm3.2(Gjb1)Kwi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188626
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Gjb2^{tm3.1(Gjb1)Kwi} removed the floxed lacZ and allowed for expression of the inserted coding sequence. Western blot analysis confirmed reduced protein expresion in embryonic skin and placenta. (J:188626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjb2 Mutation: 21 strains or lines available

References

• Original: J:188626 Dicke N, et al., Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2). J Cell Sci. 2011 Aug 15;124(Pt 16):2806-15
• All: 1 reference(s)