Ano6^tm1.2Lyj
Targeted Allele Detail

Summary

• Symbol: Ano6^tm1.2Lyj
• Name: anoctamin 6; targeted mutation 1.2, Lily Yeh Jan
• MGI ID: MGI:5441003
• Gene: Ano6 Location: Chr15:95688724-95872632 bp, + strand Genetic Position: Chr15, 50.66 cM
• Alliance: Ano6^tm1.2Lyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188263
• Parent Cell Line: GermLine mESC C57BL6/129SvJ, ASE-9005 (ES Cell)
• Strain of Origin: (C57BL/6 x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Ano6^tm1.1Lyj removed exon 2. Western blot anaylsis confirmed the absence of protein expression in platelets. (J:188263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano6 Mutation: 81 strains or lines available

References

• Original: J:188263 Yang H, et al., TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation. Cell. 2012 Sep 28;151(1):111-22
• All: 4 reference(s)