Gsk3b^tm2138.1Arte
Targeted Allele Detail

Summary

• Symbol: Gsk3b^tm2138.1Arte
• Name: glycogen synthase kinase 3 beta; targeted mutation 2138.1, TaconicArtemis
• MGI ID: MGI:5440976
• Synonyms: GSK3beta^ASKA, GSK3beta^{tm2138(V110I,L132A,F175L)Arte}, Gsk3b^tm1Arte
• Gene: Gsk3b Location: Chr16:37909363-38066446 bp, + strand Genetic Position: Chr16, 26.54 cM, cytoband B4
• Alliance: Gsk3b^tm2138.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188272
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions result in the amino acid sibstitution of isoleucine to valine at position 110 (V110I), alanine for leucine at position 132 (L132A) and leucine for phenylalanine at position 175 (F175L). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:188272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsk3b Mutation: 111 strains or lines available

References

• Original: J:188272 Chen M, et al., Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci. 2012 Sep 26;32(39):13439-53
• All: 2 reference(s)